Understanding morphogen gradients: a problem of dispersion and containment
نویسندگان
چکیده
منابع مشابه
Understanding morphogen gradients: a problem of dispersion and containment.
Protein morphogens are instructive signals that regulate growth and patterning of tissues and organs. They form long-range, dynamic gradients by moving from regions of high concentration (producing cells) to regions of low concentration (the adjacent, nonproducing developmental field). Since morphogen activity must be limited to the adjacent target field, we want to understand both how signalin...
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Individuals of the same or closely related species can vary substantially in size. Still, the proportions within and between tissues are precisely kept. This adaptation of pattern with size termed scaling, is receiving a growing attention. We review experimental evidence for scaling, and describe theoretical models for mechanisms that scale morphogen gradients. We particularly note the Expansio...
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An expansion-repression mechanism by which morphogen gradients can adjust to size and growth had been postulated as a model. Now, its molecular nature has been uncovered.
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Shh activity and at different distances from the source. The proper functioning of tissues and organs requires These observations provide unequivocal evidence that that each cell differentiate appropriately for its position. Shh acts directly on distant cells and therefore that Shh In many cases, the positional information that instructs forms a morphogen gradient in the developing neural cells...
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Some aspects of pattern formation in developing embryos can be described by nonlinear reaction-diffusion equations. An important class of these models accounts for diffusion and degradation of a locally produced single chemical species. At long times, solutions of such models approach a steady state in which the concentration decays with distance from the source of production. We present analyt...
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ژورنال
عنوان ژورنال: Current Opinion in Genetics & Development
سال: 2007
ISSN: 0959-437X
DOI: 10.1016/j.gde.2007.05.010